GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs10492096 | 1 | rs10849462 | chr12:6575992 | TAPBPL | chr12:6561177-6575601:+ | -0.17 | -3.9 | 0.000103 | Hip geometry |
| BRCA | cis | rs10849605 | 1 | rs10849605 | chr12:1064438 | RAD52 | chr12:1021255-1099219:- | -0.17 | -5.44 | 6.48E-8 | Lung cancer |
| BRCA | cis | rs1039302 | 1 | rs10849786 | chr12:121209302 | SPPL3 | chr12:121201036-121342151:- | 0.21 | 4.45 | 9.66E-6 | Quantitative traits |
| BRCA | cis | rs2275426 | 1 | rs1085243 | chr1:46544768 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.8 | 2.62E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs1085243 | chr1:46544768 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.39 | 0.000714 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs1085243 | chr1:46544768 | MUTYH | chr1:45794915-45806142:- | 0.12 | 4.76 | 2.21E-6 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs1085244 | chr1:46563680 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.72 | 6.14E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs1085244 | chr1:46563680 | MUTYH | chr1:45794915-45806142:- | 0.12 | 4.83 | 1.56E-6 | Body mass index |
| BRCA | cis | rs4803468 | 1 | rs10853751 | chr19:41903220 | B3GNT8 | chr19:41931265-41934635:- | -0.24 | -7.4 | 2.75E-13 | Height |
| BRCA | cis | rs1466788 | 1 | rs10857811 | chr1:110617688 | ALX3 | chr1:110602998-110613322:- | 0.12 | 3.72 | 0.00021 | Blood metabolite levels |
| BRCA | cis | rs11590090 | 1 | rs10857975 | chr1:113321594 | FAM19A3 | chr1:113263189-113269854:+ | -0.19 | -6.04 | 2.16E-9 | Hyperactive-impulsive symptoms |
| BRCA | cis | rs10861342 | 1 | rs10861346 | chr12:105473245 | NFYB | chr12:104510858-104532040:- | -0.2 | -3.72 | 0.000209 | IgG glycosylation |
| BRCA | cis | rs12579753 | 1 | rs10862368 | chr12:82244514 | PPFIA2 | chr12:81652880-82153109:- | 0.13 | 3.41 | 0.00068 | Resting heart rate |
| BRCA | cis | rs12579753 | 1 | rs10862371 | chr12:82249298 | PPFIA2 | chr12:81652880-82153109:- | 0.13 | 3.38 | 0.000758 | Resting heart rate |
| BRCA | cis | rs12579753 | 1 | rs10862372 | chr12:82249804 | PPFIA2 | chr12:81652880-82153109:- | 0.13 | 3.4 | 0.000705 | Resting heart rate |